TABLE 1

Demographic and clinical characteristics of patients with ESC-R Enterobacteriaceae infections and microbiological characteristics of the infections

CharacteristicNo. (%, unless otherwise noted)
All patients (n = 105)Subsequent infectionbIntestinal carriageb
No (n = 42)Yes (n = 18)No (n = 10)Yes (n = 17)
Median age in years (IQR)a5 (0.8, 14.5)4.8 (1.0, 13.5)11 (5.9, 18)2.6 (1.0, 9.3)13 (3.3, 16.2)
Female gender72 (69)30 (71)11 (61)6 (60)11 (65)
Any medical condition70 (67)36 (86)17 (94)8 (80)16 (94)
Urological condition37 (35)18 (38)8 (44)2 (20)4 (24)
Immunocompromised25 (24)14 (33)9 (50)4 (40)10 (59)
Hospitalized in year prior to index55 (52)27 (64)13 (72)7 (70)14 (83)
Median hospital days prior to index (IQR)17 (7, 57)28 (9,60)33 (15, 68)24 (7, 35)41 (16, 68)
≥14 days of antibiotics in the last 91 days46 (44)23 (55)15 (83)6 (60)14 (82)
Acquisition of index infection
    Community acquired27 (26)6 (14)1 (5)2 (20)
    Health care associated60 (57)28 (67)12 (67)8 (80)9 (53)
    Hospital acquired18 (17)8 (19)5 (28)8 (47)
Primary site of index infection
    Urine88 (84)34 (81)13 (72)8 (80)11 (65)
    Blood10 (10)6 (14)2 (11)1 (10)2 (12)
    Otherc7 (6)2 (5)3 (17)1 (10)4 (23)
Species associated with index infectiond
    E. coli92 (88)37 (88)12 (67)8 (80)12 (71)
        ST131-associated sequence type26 (25)9 (21)3 (17)2 (20)4 (24)
    K. pneumoniae11 (10)4 (10)5 (28)2 (20)5 (29)
    Klebsiella oxytoca3 (3)1 (2)1 (5)
Resistance phenotype of index isolate
    ESBL61 (58)24 (57)14 (78)7 (70)10 (59)
    AmpC42 (40)17 (41)4 (22)3 (30)6 (35)
    Carbapenem resistant2 (2)1 (2)1 (6)
  • a IQR, interquartile range.

  • b These categories are not mutually exclusive.

  • c Other sites of index infection included peritoneal fluid, bronchoalveolar lavage fluid, and wounds.

  • d Values for this variable will add up to >100% as one patient had >1 ESC-R species identified from the index isolate.