TABLE 1

Frequency of occurrence and cumulative percent distribution of ceftobiprole MICs for all European organisms tested (2005 to 2010)

Organism(s) (no. of isolates tested)No. (cumulative %) of isolates inhibited at a ceftobiprole MIC (μg/ml) of:MIC50MIC90
≤0.060.120.250.51248>8
Gram-positive bacteria
    Staphylococcus aureus (15,426)30 (0.2)163 (1.3)6,338 (42.3)5,302 (76.7)2,372 (92.1)1,149 (99.5)72 (100.0)0.51
        MSSA (11,279)30 (0.3)162 (1.7)6,316 (57.7)4,738 (99.7)29 (100.0)4 (100.0)0.250.5
        MRSA (4,147)0 (0.0)1 (0.0)22 (0.6)564 (14.2)2,343 (70.7)1,145 (98.3)72 (100.0)12
    Coagulase-negative staphylococci (5,563)236 (4.2)650 (15.9)624 (27.1)1,191 (48.6)1,757 (80.1)721 (93.1)383 (100.0)1 (100.0)12
        Methicillin-susceptible CoNS (1,317)209 (15.9)616 (62.6)455 (97.2)35 (99.8)2 (100.0)0.120.25
        Methicillin-resistant CoNS (4,246)27 (0.6)34 (1.4)169 (5.4)1,156 (32.6)1,755 (74.0)721 (91.0)383 (100.0)1 (100.0)12
    Streptococcus pneumoniae (4,443)3,428 (77.2)109 (79.6)369 (87.9)508 (99.3)23 (99.9)6 (100.0)≤0.060.5
        Penicillin susceptible (4,223)3,427 (81.2)108 (83.7)356 (92.1)325 (99.8)7 (100.0)≤0.060.25
        Penicillin nonsusceptible (217)1 (0.5)1 (0.9)13 (6.8)183 (90.0)16 (97.3)6 (100.0)0.50.5
        Penicillin intermediate (209)1 (0.5)1 (1.0)13 (7.2)179 (92.8)12 (98.6)3 (100.0)0.50.5
        Penicillin resistant (11)0 (0.0)0 (0.0)0 (0.0)4 (36.4)4 (72.7)3 (100.0)12
        Ceftriaxone nonsusceptible (202)0 (0.0)1 (0.5)4 (2.5)168 (85.6)23 (97.0)6 (100.0)0.51
        Ceftriaxone resistant (20)0 (0.0)0 (0.0)0 (0.0)3 (15.0)12 (75.0)5 (100.0)12
    Beta-hemolytic streptococci (2,981)2,957 (99.2)22 (99.9)2 (100.0)≤0.06≤0.06
        S. pyogenes (1,170)1,167 (99.7)2 (99.9)1 (100.0)≤0.06≤0.06
        S. agalactiae (1,227)1,222 (99.6)4 (99.9)1 (100.0)≤0.06≤0.06
    Viridans group streptococci (1,264)929 (73.5)173 (87.2)65 (92.3)23 (94.1)20 (95.7)22 (97.5)9 (98.2)4 (98.5)19 (100.0)≤ 0.060.25
    Enterococcus spp. (6,395)37 (0.6)476 (8.0)883 (21.8)1,321 (42.5)374 (48.3)634 (58.2)401 (64.5)145 (66.8)2,124 (100.0)2>8
        Enterococcus faecalis (3,968)31 (0.8)466 (12.5)860 (34.2)1,259 (65.9)316 (73.9)527 (87.2)348 (95.9)118 (98.9)43 (100.0)0.54
        Enterococcus faecium (2,222)0 (0.0)5 (0.2)3 (0.4)4 (0.5)24 (1.6)71 (4.8)45 (6.8)16 (7.6)2,054 (100.0)>8>8
        Other enterococci (205)6 (2.9)5 (5.4)20 (15.1)58 (43.4)34 (60.0)36 (77.6)8 (81.5)11 (86.8)27 (100.0)1>8
Gram-negative bacteria
    Enterobacteriaceae (17,480)13,398 (76.6)803 (81.2)374 (83.4)243 (84.8)159 (85.7)154 (86.6)132 (87.3)99 (87.9)2,118 (100.0)≤0.06>8
    Escherichia coli (9,609)8,194 (85.3)272 (88.1)100 (89.1)48 (89.6)26 (89.9)26 (90.2)24 (90.4)20 (90.6)899 (100.0)≤0.062
        ESBLa phenotype (1,089)73 (6.7)16 (8.2)23 (10.3)12 (11.4)14 (12.7)19 (14.4)24 (16.6)19 (18.4)889 (100.0)>8>8
        Non-ESBL phenotype (8,520)8,121 (95.3)256 (98.3)77 (99.2)36 (99.7)12 (99.8)7 (99.9)0 (99.9)1 (99.9)10 (100.0)≤0.06≤0.06
    Klebsiella pneumoniae (2,625)1,760 (67.0)93 (70.6)46 (72.3)32 (73.6)27 (74.6)16 (75.2)10 (75.6)16 (76.2)625 (100.0)≤0.06>8
        ESBL phenotype (703)14 (2.0)7 (3.0)7 (4.0)7 (5.0)16 (7.3)16 (9.5)10 (11.0)16 (13.2)610 (100.0)>8>8
        Non-ESBL phenotype (1,922)1,746 (90.8)86 (95.3)39 (97.4)25 (98.7)11 (99.2)0 (99.2)0 (99.2)0 (99.2)15 (100.0)≤0.06≤0.06
    Proteus mirabilis (733)666 (90.9)13 (92.6)7 (93.6)4 (94.1)3 (94.5)1 (94.7)0 (94.7)3 (95.1)36 (100.0)≤0.06≤0.06
    Enterobacter spp. (1,909)1,237 (64.8)118 (71.0)54 (73.8)42 (76.0)35 (77.8)77 (81.9)79 (86.0)46 (88.4)221 (100.0)≤0.06>8
    Citrobacter spp. (414)301 (72.7)15 (76.3)6 (77.8)14 (81.2)23 (86.7)20 (91.5)5 (92.8)4 (93.7)26 (100.0)≤0.062
    Serratia spp. (711)405 (57.0)140 (76.7)51 (83.8)46 (90.3)23 (93.5)8 (94.7)7 (95.6)4 (96.2)27 (100.0)≤0.060.5
    Indole-positive Proteus spp. (479)357 (74.5)2 (74.9)2 (75.4)2 (75.8)0 (75.8)0 (75.8)1 (76.0)3 (76.6)112 (100.0)≤0.06>8
    Pseudomonas aeruginosa (3,434)2 (0.1)4 (0.2)11 (0.5)113 (3.8)826 (27.8)806 (51.3)458 (64.6)489 (78.9)725 (100.0)2>8
        Ceftazidime susceptible (2,588)2 (0.1)3 (0.2)11 (0.6)112 (4.9)812 (36.3)761 (65.7)327 (78.4)325 (90.9)235 (100.0)28
        Ceftazidime nonsusceptible (846)0 (0.0)1 (0.1)0 (0.1)1 (0.2)14 (1.9)45 (7.2)131 (22.7)164 (42.1)490 (100.0)>8>8
    Acinetobacter spp. (1,146)59 (5.1)37 (8.4)96 (16.8)85 (24.2)45 (28.1)18 (29.7)12 (30.7)8 (31.4)786 (100.0)>8>8
    Stenotrophomonas maltophilia (420)0 (0.0)1 (0.2)0 (0.2)0 (0.2)0 (0.2)0 (0.2)0 (0.2)2 (0.7)417 (100.0)>8>8
    Haemophilus influenzae (2,052)1,965 (95.8)76 (99.5)8 (99.9)3 (100.0)≤0.06≤0.06
    Moraxella catarrhalis (200)107 (53.5)70 (88.5)20 (98.5)3 (100.0)≤0.060.25
  • a ESBL, extended-spectrum β-lactamase.