TABLE 3

Kinetic parameters with avibactam

Parameterβ-Lactamase
CMY-2P99PDC-1
Ki app (µM) avibactam26 ± 3Not availableNot available
kcat/kinact1Not availableNot available
k2/K (M−1 s−1)(4.9 ± 0.5) × 104(5.1 ± 0.1) × 103a(2.9 ± 0.1) × 103a
koff (s−1)(3.7 ± 0.4) × 10−4(3.8 ± 0.2) × 10−5a(1.9 ± 0.60) × 10−3a
Kd (nM)b7.5 ±0.77a660a
  • a Data from reference 6.

  • b Kd, dissociation constant.