TABLE 2

Minimal inhibitory concentration and minimal biofilm inhibition concentration of antibiotics alone or in combination with d-amino acids

Antimicrobial agentaClassPlanktonic MICb (μg/ml) for:Biofilm MBICb (μg/ml) for:
S. aureus UAMS-1S. aureus SAMMC-700S. aureus UAMS-1S. aureus SAMMC-700
CLILincosamide0.50.5256512
CLI + d-AA0.250.532128
CFZCephem0.5165121,024
CFZ + d-AA0.5165121,024
OXAPenicillin18256>1,024
OXA + d-AA18256>1,024
RIFAnsamycin0.50.53264
RIF + d-AA0.50.588
VANGlycopeptide0.51256512
VAN + d-AA0.51128128
  • a CLI, clindamycin; CFZ, cefazolin; OXA, oxacillin; RIF, rifampin; VAN, vancomycin.

  • b MIC and minimum biofilm inhibition concentration (MBIC) of the antibiotic (μg/ml) alone or in combination with an equimolar mixture of d-Phe/d-Trp/d-Met (5 mM).