TABLE 3

MIC and minimal biofilm inhibition concentration of antibiotics alone or in combination with d-amino acids

Antimicrobial agentaClassPlanktonic MICb (μg/ml) for:Biofilm MBICb (μg/ml) for:
SAMMC-189SAMMC-418SAMMC-189SAMMC-418
AMKAminoglycoside1616512>1,024
AMK + d-AA816512>1,024
CSLipopeptide11256256
CS + d-AA113264
CIPFluoroquinolone48128256
CIP + d-AA483232
IMICarbapenem12864256256
IMI + d-AA12864256128
TAZCephem162512>1,024
TAZ + d-AA82512512
  • a AMK, amikacin; CS, colistin; CIP, ciprofloxacin; IMI, imipenem; TAZ, ceftazidime.

  • b MIC and minimum biofilm inhibition concentration (MBIC) of the antibiotic (μg/ml) alone or in combination with an equimolar mixture of d-Phe/d-Trp/d-Met (5 mM).