TABLE 3

In vitro and in vivo daily release rates and in vitro-in vivo correlation

Drug (IVR formulation)aRelease rate (mean ± SD) (mg day−1)IVIVCb
In vitroIn vivo
TDF (TDF-FTC)3.41 ± 0.330.68 ± 0.260.20
FTC (TDF-FTC)3.39 ± 0.842.50 ± 0.580.74
TDF (TDF-FTC-MVC)1.59 ± 0.290.75 ± 0.300.47
FTC (TDF-FTC-MVC)2.84 ± 0.171.05 ± 0.320.37
MVC (TDF-FTC-MVC)1.31 ± 0.170.86 ± 0.070.66
  • a n = 3 for both IVR formulations.

  • b In vivo release rate divided by in vitro release rate.