TABLE 3

Endpoints of worm motility determined by noise amplitudes at different concentrations of racemic and enantiomeric PZQ and 4-OH metabolites

CompoundMean motility endpoint [h postinjection (SD)] at concn (μg/ml) of:
0.0410.25150
Rac-PZQ>120<3<3
R-PZQ<3<3<3
S-PZQ>120>120>120
Rac-trans-4-OH-PZQ>120>120<3
R-trans-4-OH-PZQ>12075 (5)<3
S-trans-4-OH-PZQ>120>120>120
Rac-cis-4-OH-PZQ>12096.7 (16.1)<3
R-cis-4-OH-PZQ>120<3<3
S-cis-4-OH-PZQNTaNT>120
  • a NT, not tested.