TABLE 4

Total and female WBRs obtained with racemic PZQ, R-PZQ, and S-PZQ at different dosages in mice harboring adult S. mansoni

Compound and dose (mg/kg)No. of miceMean WBR [% (SD)]ED50 (mg/kg)Eudysmic ratio
Rac PZQ
    400494.1 (8.6)246.5
    100b615 (9.5)
R-PZQ
    4003100.0 (0)95.4
    200698.1 (2.3)
    100652.0 (30.8)
S-PZQ
    800619.6 (22.2)3,066,777a32,136
    400418.0 (21.4)
  • a Extrapolated value determined by CompuSyn.

  • b Data from reference 36.