TABLE 2

Final population PK model parameter estimates and standard errors

ParameteraFinal estimated mean value (% SEM)
Population meanMagnitude of interindividual variability (CV %)
Vcu (liters)66.1 (18.6)139 (29.4)
Vp1u (liters)582 (7.51)48.0 (17.3)
CLd1u (liters/h)60.8 (11.0)35.1 (30.4)
Vp2u (liters)211 (10.2)64.5 (19.0)
CLd2u (liters/h)199 (10.1)39.3 (25.8)
CLtu (liters/h)120 (4.04)17.8 (14.4)
Bmax12.7
KD2.07
SDin0.0005
SDsl0.217 (2.62)
  • a Volumes and clearances are scaled to free-drug concentrations. The minimum value of the objective function is −1,888. Vp1u, volume of distribution of the first peripheral compartment; Vp2u, volume of distribution of the second peripheral compartment; CLd2u, second distributional clearance; Bmax, parameter describing the maximum extent of protein binding; SDin, intercept (additive) term for residual variability model for plasma concentrations; SDsl, slope (proportional) term for residual variability model.