Parameter^{a} | Final estimated mean value (% SEM) | |
---|---|---|

Population mean | Magnitude of interindividual variability (CV %) | |

V_{c}u (liters) | 66.1 (18.6) | 139 (29.4) |

V_{p1}u (liters) | 582 (7.51) | 48.0 (17.3) |

CL_{d1}u (liters/h) | 60.8 (11.0) | 35.1 (30.4) |

V_{p2}u (liters) | 211 (10.2) | 64.5 (19.0) |

CL_{d2}u (liters/h) | 199 (10.1) | 39.3 (25.8) |

CL_{t}u (liters/h) | 120 (4.04) | 17.8 (14.4) |

B_{max} | 12.7 | |

K_{D} | 2.07 | |

SD_{in} | 0.0005 | |

SD_{sl} | 0.217 (2.62) |

↵a Volumes and clearances are scaled to free-drug concentrations. The minimum value of the objective function is −1,888.

*V*_{p1}*u*, volume of distribution of the first peripheral compartment;*V*_{p2}*u*, volume of distribution of the second peripheral compartment; CL_{d2}*u*, second distributional clearance;*B*_{max}, parameter describing the maximum extent of protein binding; SD_{in}, intercept (additive) term for residual variability model for plasma concentrations; SD_{sl}, slope (proportional) term for residual variability model.