TABLE 3

Response to treatment in therapeutic efficacy studies in Zaire and Uíge Provinces, Angola, in 2013

ParameterResult in study arm
ALDP
Zaire (n = 79)Uíge (n = 78)Zaire (n = 80)Uíge (n = 83)
ACPR, n (%)61 (77)72 (92)79 (99)83 (100)
Treatment failure, n (%)18 (23)6 (7.7)1 (1.2)0 (0)
    Early1 (1.3)0 (0)0 (0)0 (0)
    Late17 (22)6 (7.7)1 (1.2)0 (0)
        Day 141 (1.3)0 (0)0 (0)0 (0)
        Day 2110 (13)3 (3.8)0 (0)0 (0)
        Day 286 (7.6)3 (3.8)1 (1.2)0 (0)
    Reinfections10 (13)4 (5.1)1 (1.2)0 (0)
    Recrudescence7 (8.9)2 (2.6)0 (0)0 (0)
    Day 3 clearance, % (95% CI)100 (96–100)97.6 (92–100)100 (96–100)100 (96–100)
Cumulative success rate on day 28, % (95% CI)
    PCR uncorrected77.4 (69–87)92.3 (87–98)98.8 (96–100)100a
    PCR corrected89.6 (83–97)97.4 (94–100)100a100a
Proportion of ACPR on day 28, % (95% CI)
    PCR uncorrected77.2 (66–86)92.3 (84–97)98.8 (93–100)100 (96–100)
    PCR corrected88.4 (78–95)97.3 (91–100)100 (95–100)100 (96–100)
  • a Confidence intervals were not calculated for the Kaplan-Meier estimator when the rate was 100%.