TABLE 2

Summary of whole-genome sequencing resultsa

Resistant populationGene IDbDescriptioncnt positionBase callNo. of reads% readsdAA changee
WTMutWTMutWTMut
08138R1PF3D7_01069002-C-methyl-d-erythritol 4-phosphate cytidylyltransferase730TA22732099.699.4L244I
PF3D7_1247500Putative protein kinase2632GT1107397.3100D878Y
PF3D7_1456700Conserved Plasmodium protein1384GA28041393.996.4E462K
08138R2PF3D7_01069002-C-methyl-d-erythritol 4-phosphate cytidylyltransferase2062GC856910091.3E688Q
PF3D7_0302900Putative exportin1620AT1549161.797.8E540D
PF3D7_1478600Plasmodium exported protein1241CT665910096.6T414I
08138R3PF3D7_01069002-C-methyl-d-erythritol 4-phosphate cytidylyltransferase730TA151188100100L244I
PF3D7_1417400Cyclic nucleotide binding protein pseudogene10270GT1129455.3100E3424*
  • a AA, amino acid; Mut, mutant; nt, nucleotide; WT, wild type. WT calls match the 3D7 reference genome.

  • b Gene ID, PlasmoDB gene identification number.

  • c Basic gene description based on PlasmoDB functional assignments.

  • d % reads, percentages of reads corresponding to the WT call or Mut call.

  • e Asterisk indicates stop codon.