TABLE 1

Activity of plazomicin and selected antimicrobial agents against A. baumannii isolates included in the study

Isolate type and antimicrobial agentMIC (μg/ml)Activity (%)a
MIC50MIC90RangeSIR
Carbapenem resistant (n = 69 isolates)
    Plazomicin16160.5–64
    Amikacin322560.5–51246.44.349.3
    Imipenem25651232–>51200100
    Meropenem1282564–512018.881.2
    Gentamicin>512>5121–>512104.585.5
    Tobramycin1282560.25–51220.32.976.8
    Fosfomycin1285128–5121.498.6
    Tigecycline220.25–233.366.70
    Colistin121–210000
Carbapenem susceptible (n = 8 isolates)
    Plazomicin1160.5–16
    Amikacin8162–1610000
    Imipenem121–210000
    Meropenem0.520.25–210000
    Gentamicin64>5120.5–>51237.5062.5
    Tobramycin8320.5–3250050
    Fosfomycin128>51264–>51200100
    Tigecycline0.12520.125–210000
    Colistin11110000
  • a S, susceptible; I, intermediate susceptibility; R, resistant.