TABLE 1

Baseline characteristics of isolates for which ex vivo assays were performed

Baseline characteristicNaphthoquineMethylene blue
P. falciparum (n = 25)P. vivax (n = 38)P. falciparum (n = 63)P. vivax (n = 50)
Isolates reaching harvest (no. [%])21 (84.00)29 (76.32)52 (82.54)41 (82.00)
Delay from venepuncture to start of culture (median [range]) (min)160 (85–310)178 (55–330)125 (60–310)148 (55–330)
Duration of assay (median [range]) (h)44 (32–48)47 (42–50)45 (32–50)46 (32–50)
Parasitemia (geometric mean [95% CIa]) (asexual parasites/μl)24,10225,00113,34322,454
(15,856–36,637)(17,487–35,742)(11,059–16,099)(16,531–30,501)
Parasites at ring stage initially (median [range]) (%)100b96 (71–99)100b96 (70–99)
Schizont count at harvest (mean [range]) (%)50 (16–76)45 (13–70)42 (14–75)43 (13–70)
  • a CI, confidence interval.

  • b No range given (all values were 100%).