TABLE 2

MICs of test compounds with Qnr-containing strains

E. coli strainPMQRaMIC (μg/ml)
Cipro floxacinCoumermycin A1NovobiocinGyramide ACubist CB-220Cubist CB-241Trius C3Trius C4
J530.01682,048>8>10>101.280.64
J53 pMG252qnrA10.51216512>8>10>101.280.64
J53 pMG298qnrB1 aac(6)Ib-cr0.512162,048>8>10>100.640.64
J53 pMG306qnrS12.04816512>8>10>101.280.64
EW1b ΔtolC0.004411.0240.320.160.0080.04
EW1b pMG253qnrA10.128411.0240.160.080.0040.04
  • a PMQR, plasmid-mediated quinolone resistance.