TABLE 4

Drug resistance does not impact clinical parameters of disease with combination therapy

ParameterCLSI susceptibility classification
FluconazoleAmphotericin B
SusceptibleDose dependentResistantPaSusceptibleResistant
CSF during follow-up (n = 73)
    No.46225721
    Mean (SD) EFA−0.33 (0.35)−0.26 (0.20)−0.24 (0.15)0.59−0.31 (0.30)
    No. (%) culture positive after CM treatment26 (56.5)17 (77.3)1 (20.0)0.0443 (59.7)1
Initiated ART during follow-up (n = 62)
    No.38204611
    No. (%) of IRIS4 (10.5)3 (15.0)0 (0)0.817 (11.5)0
Vital status at day 60 known (n = 90)
    No.58275891
    No. (%) of deaths29 (50.0)11 (40.7)1 (20.0)0.3941 (46.1)0
  • a P value for EFA is from the generalized linear model. P values for proportions are from Fisher's exact tests.