TABLE 3

Meropenem concentrations in plasma (total), epithelial lining fluid, and alveolar macrophages at sampling time of bronchoscopy and bronchoalveolar lavagea

BAL sampling time (h)Mean concn (μg/ml) ± SD of meropenem in:
Total plasmaELFAM
1.541.2 ± 5.0221.4 ± 3.96BQL
3.2547.7 ± 7.2828.3 ± 6.69BQL
423.8 ± 4.3016.1 ± 4.77BQL
67.24 ± 2.797.51 ± 5.29BQL
81.36 ± 0.512.51 ± 1.13BQL
  • a ELF, epithelial lining fluid; AM, alveolar macrophages; BAL, bronchoalveolar lavage; BQL, below the quantitative limit of detection (0.01 μg/ml).