TABLE 3

qnrB protects gyrBA from ciprofloxacin and norfloxacin inhibition in E. coli J53 (gyrA S83L)

Host cellsPlasmidMIC (μg/ml) for:
CiprofloxacinNorfloxacin
pTrcHisApTrcHisA-qnrB1pTrcHisApTrcHisA-qnrB1
E. coli J53 (gyrA S83L)None0.5112
pET28a0.5112
pET28a-gyrB0.5112
pET28a-gyrA0.2510.52
pET28a-gyrBA0.12510.252