TABLE 4

RPX7009 concentrations in plasma (total), epithelial lining fluid, and alveolar macrophages at sampling time of bronchoscopy and bronchoalveolar lavagea

BAL sampling time (h)Mean concn ± SD or median concn (range) of RPX7009 in μg/ml in:
Total plasmaELFAM
1.542.1 ± 5.0018.6 ± 3.762.28 (1.29–4.69)
3.2551.1 ± 6.7826.1 ± 7.124.68 (2.08–25.1)
428.2 ± 5.3215.7 ± 3.366.94 (1.26–8.36)
610.8 ± 2.828.04 ± 5.813.85 (2.32–95.9)
82.74 ± 1.122.61 ± 1.352.35 (2.22–11.7)
  • a ELF, epithelial lining fluid; AM, alveolar macrophages; BAL, bronchoalveolar lavage.