TABLE 3

Bootstrap estimates of the final micafungin model

ParameteraBootstrapFinal model
Estimate95% CIEstimate95% CI
Population mean
    CL (liter/h)0.3560.338, 0.3730.3560.338, 0.373
    V1 (liter)1.210.796, 1.671.210.951, 1.46
    Q (liter/h)5.653.80, 7.835.544.16, 6.92
    V2 (liter)4.644.18, 5.024.624.33, 4.90
    Allometric scaling exponent0.7820.719, 0.8430.7870.730, 0.844
    Fixed-effect exponent of AST−0.0623−0.117, −0.0180−0.0601−0.103, −0.0170
    Fixed-effect exponent of total bilirubin−0.0493−0.0937, −0.00652−0.0492−0.0944, −0.00393
Intersubject variability
    ωCL20.07520.0583, 0.09520.07630.0584, 0.0943
    ωV120.8780.513, 1.280.9530.606, 1.30
    ωQ21.481.00, 1.991.521.13, 1.91
    ωV220.02650.00800, 0.05210.02770.00590, 0.0494
Residual error
    εprop20.03130.0268, 0.03650.03130.0263, 0.0364
    εprop-22b0.1290.0786, 0.1780.1300.0742, 0.185
    εconst20.004640.000761, 0.01070.004610, 0.00956
  • a AST, aspartate aminotransferase; CI, confidence interval; CL, clearance from the central compartment; Q, intercompartmental clearance; V1, volume of the central compartment; V2, volume of the peripheral compartment; εprop, proportional residual error; εconst, constant residual error; ω, variance of the intersubject variability of the specified parameter.

  • b Different proportional error applied to patients (n = 25) in study 463-CL-2101 with highly variable trough screen data.