TABLE 4

Parameter estimate of M1 and M5 base and final models

ParameteraBase modelFinal model
EstimateError (CV%)EstimateError (CV%)
M1
    Population mean
        KP0.1044.90.1073.4
        K300.01349.10.01346.4
        Fixed-effect exponent of albuminNAcNA−0.33828.9
    Intersubject variability
        ωKP20.067220.20.062719.3
        ωK3020.078329.10.074152.0
    Residual error
        εprop20.019933.80.019932.1
        εprop-22b0.033422.40.033727.1
        εconst20.0011821.40.0011819.7
M5
    Population mean
        KP0.1173.80.09212.1
        K300.066811.30.066417.2
        Fixed-effect exponent of ageNANA−0.49213.3
        Fixed-effect exponent of total bilirubinNANA1.5518.0
    Intersubject variability
        ωKP20.41111.90.29221.7
        ωK3020.23272.00.216117.6
    Residual error
        εprop20.019613.70.019618.7
        εprop-22b0.064730.30.064829.9
        εconst20.00095627.90.00098335.1
  • a CV%, coefficient of variation; K30, elimination rate constant; KP, exposure relative to micafungin exposure; εprop, proportional residual error; εconst, constant residual error; ω, variance of the intersubject variability of the specified parameter.

  • b Different proportional error applied to patients (n = 25) in study 463-CL-2101 with highly variable trough screen data.

  • c NA, not applicable.