TABLE 1

Ombitasvir EC50s against stable subgenomic replicon cell lines

HCV replicon subtypeMean EC50 (pM) ± SD with human plasma ata:
0%40%
1a-H7714 ± 6.8186 ± 63
1b-Con15.0 ± 1.956 ± 15
2a12 ± 2.7NDb
2a JFH-1c0.82 ± 0.18ND
2b4.3 ± 1.2ND
3a19 ± 5.8ND
4a1.7 ± 0.88ND
5a3.2 ± 1.6ND
6a366 ± 125ND

  • ↵a Both the 0% and 40% human plasma assays also contain 5% fetal bovine serum.

  • ↵b ND, not determined.

  • ↵c Studies conducted at Southern Research Institute using qRT-PCR assay.