TABLE 2

Dose-proportionality assessment of posaconazole after i.v. administration of a single doseb

ParameterSlope90% CIEstimated fold increase (vs 6-fold dose increase)a90% CI
LowerUpperLowerUpper
Cmax1.1591.0181.3007.9796.19710.27
AUC0–last1.3281.2151.44110.88.82413.21
AUC0–∞1.3021.1911.41410.328.45212.59
  • a The dose range was 50 to 300 mg, i.e., a 6-fold increase from lowest to highest dose.

  • b AUC0–∞, area under the concentration-time curve from time zero to infinity; AUC0–last, AUC from time zero to the time of the last measurable sample; CI, confidence interval; Cmax, maximum observed plasma drug concentration.