TABLE 3

Number of subjects with thrombophlebitis and infusion site reactions after single-dose i.v. administration of placebo, vehicle, or posaconazole in part 1

Type of adverse eventNo. (%) of subjects with thrombophlebitis/infusion site reactions who received:Total (n = 72)
Placebo (n = 18)Posaconazole (mg)
0a (n = 9)50 (n = 9)100 (n = 9)200 (n = 9)250 (n = 9)300 (n = 9)
Thrombophlebitisb0 (0)0 (0)0 (0)0 (0)1 (11)0 (0)1 (11)2 (3)
Infusion site reactions0 (0)2 (22)1 (11)0 (0)1 (11)2 (22)3 (33)9 (13)
  • a Subjects received vehicle (cyclodextrin) only.

  • b In both subjects, thrombophlebitis was preceded by infusion site reactions that started on day 1.