TABLE 1

Biological characterization of compound 4 against intracellular amastigotes of Sylvio X-10 strain infecting Vero cellsa

CompoundEC50 (μM)EC90 (μM)SIVb
40.72 ± 0.0840.2 ± 3.4433
Bnz3.3 ± 0.3c300
Nfx0.45 ± 0.012.4 ± 0.2200
  • a Each compound concentration was evaluated in quadruplicate for 72 h.

  • b SIV, selectivity index, EC50,Vero cells/EC50,T. cruzi (amastigotes, Sylvio X-10).

  • c —, not studied.