TABLE 3

Influenza virus susceptibility to peramivir

Day after treatmentPeramivir IC50 (nM) fora:
H1N1 pdm09H3N2B
Day 0 (n = 2/6/7)b0.15 ± 0.02 (0.15, 0.14–0.17)0.18 ± 0.04 (0.20, 0.12–0.22)1.05 ± 0.27 (1.00, 0.72–1.49)
Day 1 (n = 3/6/6)0.13 ± 0.05 (0.11, 0.10–0.19)0.20 ± 0.02 (0.20, 0.18–0.24)1.45 ± 0.43 (1.37, 0.97–1.22)
Day 2 (n = 1/6/6)0.240.16 ± 0.02 (0.16, 0.13–0.20)1.09 ± 0.20 (1.02, 0.83–1.36)
Day 3 (n = none/1/1)None0.170.94
Day 4 (n = none/1/0)None0.22None
Day 5 (n = 1/0/3)0.10None1.04 ± 0.12 (0.99, 0.96–1.19)
  • a Data are mean ± SD (median, range).

  • b Number of H1N1 pdm09/H3N2/B isolates.