TABLE 4

Predictive peramivir PK/PD in the upper respiratory tract

Administration regimenaAUCb (nM · h)cPredicted % time (h) above ICd at required peramivir concn in the upper respiratory tract atc:
50 nM100 nM200 nM300 nM
1109,10310010090.7 (108.9)e76.8 (92.2)e
2113,43978.6 (94.3)e67.1 (80.5)e55.6 (66.7)e48.9 (58.7)e
3216,25410010010097.8 (117.4)e
4224,38387.4 (104.9)e76.3 (91.5)e65.2 (78.2)e58.7 (70.4)e
  • a Regimen 1, 5 mg/kg every 12 h for 5 days; regimen 2, 10 mg/kg every 24 h for 5 days; regimen 3, 10 mg/kg every 12 h for 5 days; and regimen 4, 20 mg/kg every 24 h for 5 days.

  • b AUC, area under the concentration-time curve.

  • c From 0 to 120 h after the initial peramivir administration.

  • d IC, inhibitory concentration.

  • e Duration above the IC from 0 to 120 h after the initial administration of peramivir.