TABLE 1

GES variants isolated from clinical isolates, in relation to their hydrolysis profile

TABLE 1
  • a The GES-1 to GES-24 clinical variants are listed according to the GES-type β-lactamases list at http://lahey.org/studies/other.asp.

  • b Amino acid positions were assigned according to Ambler. The amino acid changes compared to wild-type GES-1 are indicated.

  • c When available, the hydrolysis profile of each variant was estimated from published MICs. + and −, hydrolysis and no hydrolysis, respectively, with dark-gray shaded cells indicating increased hydrolysis, and light-gray shaded cells indicating decreased hydrolysis, compared to wild-type GES-1. For each variant, the amino acid substitution responsible for the change in the hydrolytic profile is framed. Of note, these comparisons are only indicative, given that the bacterial species and the genetic support differ according to the study.