TABLE 1

Dalbavancin PK parameters after multiple dosinga

ParameterResults in:
Cohort I (4th infusion)Cohort II (6th infusion)Cohort III (8th infusion)
AUC0–τ (μg · h/ml)10,203 (14.9)12,292.79 (17.8)12,173 (17.7)
Cmax (μg/ml)160.0 (14.0)187.0 (13.1)179.7 (11.0)
Cmin (μg/ml)33.0 (19.3)42.9 (17.4)40.2 (20.0)
Tmax (median [range]) (h)0.5 (0.5–1.0)0.5 (0.5–0.5)0.5 (0.5–1.0)
Accumulation ratio (R)0.89 (10.7)0.96 (12.5)0.91 (17.0)
  • a On day 1, subjects received 1,000 mg of dalbavancin i.v. over 30 min, followed by 500 mg i.v. over 30 min weekly for a total of 4 weekly infusions (cohort I), 6 weekly infusions (cohort II), or 8 weekly infusions (cohort III). Results are means (standard deviations [SD]) unless otherwise indicated.