TABLE 2

Minimum serum concentrations on day of weekly dose

DayCmin (mean μg/ml [% CVa]) in:
Cohort ICohort IICohort III
833.0 (18.5)38.1 (10.7)40.4 (18.7)
1531.9 (16.3)39.7 (15.4)38.7 (16.8)
2233.1 (18.9)39.0 (16.4)36.5 (17.7)
29NAb38.7 (13.9)38.2 (17.7)
36NA43.2 (17.9)38.0 (16.2)
43NANA38.5 (18.3)
50NANA40.6 (19.7)
  • a CV, coefficient of variation.

  • b NA, not applicable.