TABLE 2

Mutations in embCAB among 139 MDR-TB isolates

Mutations in:No. of isolates
embCembAembBEMB resistant (n = 79)EMB susceptible (n = 60)
Arg738Gln01
C(−16)A01
G(−43)Ca10
Gly154Sera01
Thr270Proa01
Ala291Thra01
Gly554Aspa10
Val417MetaThr652Lysa01
Pro763Sera01
C(−16)AVal50Alaa/Gln497Pro10
C(−16)GVal50Alaa/Gln497Lys10
C(−16)GMet306Ile10
C(−16)TMet306Ile10
Met306Ile/Asp354Ala10
Met306Ile/Gly406Ser10
Met306Ile/Thr643Ilea10
Met306Ile145
C(−16)TMet306Leu10
Met306Leu22
Met306Val/Ile563Leu01
Met306Val/Pro907Sera01
Met306Val/Asp1024Asn10
C(−12)TMet306Val10
Pro150SeraC(−12)T/Ala331ThraMet306Val10
C(−16)TMet306Val10
Asp4AsnMet306Val10
Pro769ThraMet306Val10
Gln725ArgaMet306Val10
Val885MetaMet306Val01
Met306Val215
Tyr319Asp10
C(−11)ATyr319Cys10
Tyr319Cys10
Asp328Tyr10
C(−8)T/Gly200SerAsp354Asn/Ala679Thra10
C(−12)TAsp354Ala10
Asp354Ala01
Asp354Asn01
G(−43)CaAsn399Thr10
Gly406Ala42
Glu951AspaGly406Asp01
Gly406Asp22
C(−16)AGly406Ser10
Gly406Ser20
Ser412Proa10
Val42AlaaGln497Arg01
Gln497Arg11
Gln497Lys11
Ile563Leu01
C(−16)GGly603Arga01
Thr642Alaa/His1002Arg10
His1002Arg10
Asp1024Asn10
  • a Mutation not previously reported.