TABLE 3

Summary of sequence analysis of embCAB and phenotypic drug susceptibility testing

Locus or codonaNo. of MDR-TB isolatesP valueSensitivityb (%)Specificityc (%)Accuracyd (%)
ResistantSusceptible
With mutationWithout mutationWith mutationWithout mutation
embC2774560.442.593.341.7
embA UR14652580.01e17.796.751.8
embA(−16)7722580.348.996.746.8
embA ORF5746540.636.390.042.4
embB74527330.00f93.755.077.0
embB306–49771825350.00f89.958.376.3
embB306502915450.00f63.375.068.3
embB40610695550.4212.791.746.8
embB4974753571.005.195.043.9
embB and/or embA UR75428320.00f94.953.377.0
embB306–497 and/or embA UR72726340.00f91.156.776.3
  • a UR, upstream region; ORF, open reading frame.

  • b Sensitivity = no. of resistant isolates with mutation/total no. of resistant isolates.

  • c Specificity = no. of susceptible isolates without mutation/total no. of susceptible isolates.

  • d Accuracy = (no. of resistant isolates with mutation + no. of susceptible isolates without mutation)/(total no. of resistant isolates + total no. of susceptible isolates).

  • e P < 0.05.

  • f P < 0.01.