TABLE 1

Intracellular pH of metal dithiocarbamate-treated L. major promastigotes grown in normal (pH 7.2) or acidic (pH 5.5) media

pHeaTreatmentpHib
7.2Untreated6.93 ± 0.02
Manebc6.68 ± 0.07d
Zinebc6.72 ± 0.03d
Propinebc6.71 ± 0.06d
5.5Untreated6.81 ± 0.03
Manebe6.46 ± 0.05d
Zinebe6.53 ± 0.04d
Propinebe6.49 ± 0.06d
  • a pHe indicates the pH of the growth medium.

  • b pHi values are experimentally determined intracellular pH values of L. major promastigotes grown in the absence (untreated) or presence of metal dithiocarbamates. Means ± SD of values from triplicate experiments are shown.

  • c Treatment with 0.625 μM of the respective metal dithiocarbamate.

  • d Significant difference (P < 0.05) with respect to the untreated control.

  • e Treatment with 0.078 μM of the respective metal dithiocarbamates.