TABLE 1

Cumulative MIC distribution for RX-P873 when tested against 657 Enterobacteriaceae and 402 nonfermentative Gram-negative bacilli

Organism group (no. of strains tested)No. of strains (cumulative %) at an MIC (μg/ml) of:MIC (μg/ml)
≤0.0150.030.060.120.250.5124816≥32MIC50MIC90
Enterobacteriaceae (657)0 (0.0)0 (0.0)2 (0.3)188 (28.9)287 (72.6)122 (91.2)39 (97.1)15 (99.4)1 (99.5)1 (99.7)1 (99.8)1 (100.0)0.250.5
    E. coli (202)0 (0.0)0 (0.0)2 (1.0)111 (55.9)78 (94.6)8 (98.5)2 (99.5)1 (100.0)0.120.25
    K. pneumoniae (202)0 (0.0)0 (0.0)0 (0.0)52 (25.7)117 (83.7)28 (97.5)2 (98.5)3 (100.0)0.250.5
    E. cloacae (50)0 (0.0)0 (0.0)0 (0.0)3 (6.0)21 (48.0)23 (94.0)3 (100.0)0.50.5
    E. aerogenes (50)0 (0.0)0 (0.0)0 (0.0)14 (28.0)30 (88.0)5 (98.0)1 (100.0)0.250.5
    C. freundii (51)0 (0.0)0 (0.0)0 (0.0)5 (9.8)22 (52.9)19 (90.2)4 (98.0)1 (100.0)0.250.5
    Proteus spp. (51)a0 (0.0)0 (0.0)0 (0.0)1 (2.0)4 (9.8)9 (27.5)24 (74.5)9 (92.2)1 (94.1)1 (96.1)1 (98.0)1 (100.0)12
    S. marcescens (51)0 (0.0)0 (0.0)0 (0.0)2 (3.9)15 (33.3)30 (92.2)3 (98.0)1 (100.0)0.50.5
Nonfermentative bacilli (402)0 (0.0)0 (0.0)0 (0.0)9 (2.2)41 (12.4)85 (33.6)136 (67.4)77 (86.6)45 (97.8)9 (100.0)14
    P. aeruginosa (200)0 (0.0)0 (0.0)0 (0.0)0 (0.0)1 (0.5)5 (3.0)76 (41.0)70 (76.0)39 (95.5)9 (100.0)24
    A. baumannii (202)0 (0.0)0 (0.0)0 (0.0)9 (4.5)40 (24.3)80 (63.9)60 (93.6)7 (97.0)6 (100.0)0.51
  • a Includes the following species (no.): Proteus mirabilis (30), Morganella morganii (11), Proteus vulgaris (4), Providencia rettgeri (4), and Providencia stuartii (2).