TABLE 2

Outcome of 3-day treatment with flucloxacillin of experimental endocarditis caused by mecC-MRSA isolates

StrainNo. of sterile vegetations/total no. of vegetations (%; median [range] log10 CFU/g of vegetation) for treatment group:
ControlFlucloxacillina
NCTC 135520/5 (0; 8.5 [6.7–8.9])10/11 (91b; 2.0 [2.0–2.7])c
11000/5 (0; 8.8 [8.1–9.1])9/9 (100); 2.0 [2.0–2.0])
8200/5 (0; 7.7 [6.4–9.0])6/8 (75); 2.0 [2.0–4.1])c
S0900/5 (0; 8.0 [7.6–9.4])9/10 (90b; 2.0 [7.0–3.2])c
S1290/5 (0; 8.7 [8.3–9.1])8/10 (80b; 2.0 [2.0–6.0])c
  • a Simulation in rats of human pharmacokinetics following 2 g i.v. every 6 h.

  • b P < 0.05 compared to untreated controls by Fisher's exact test.

  • c P < 0.005 compared to untreated controls by Mann-Whitney test.