TABLE 1

Demographic and clinical characteristics of patients with PVO who received antibiotics before the acquisition of tissue culture specimens

Patient parameterTotal (n = 58)Culture positive (n = 28)Culture negative (n = 30)P value
Age (yr)a66.1 ± 14.364.6 ± 13.767.4 ± 14.80.375
No. (%) of males24 (41.4)15 (53.6)9 (30.0)0.069
No. (%) with underlying disease/treatment
    Hypertension16 (27.6)8 (28.6)8 (26.7)0.871
    Diabetes mellitus13 (22.4)7 (25.0)6 (20.0)0.648
    Liver cirrhosis2 (3.4)1 (3.6)1 (3.3)1.000b
    Spinal procedure in previous yr14 (24.1)6 (21.4)8 (26.7)0.641
    Spinal surgery in previous yr7 (12.3)4 (14.3)3 (10.3)0.706b
No. (%) with:
    Feverc20 (34.5)10 (35.7)10 (33.3)0.849
    Spine area pain56 (96.9)26 (92.9)30 (100)0.229b
    Motor weaknessd10 (17.2)5 (17.9)5 (16.7)1.000b
    Sepsise19 (32.8)12 (42.9)7 (23.3)0.113
No. of WBC/mm3f10,050 (8,215–12,405)10,480 (8,742–14,350)9,450 (7,950–11,350)0.141
CRP level (mg/dl)f11.0 (5.0–18.8)17.2 (11.0–24.4)6.5 (1.7–11.3)<0.001
No. (%) with paravertebral abscesses13 (22.4)7 (25.0)6 (20.0)0.648
No. (%) with epidural abscesses28 (48.3)13 (46.4)15 (50.0)0.786
No. (%) with psoas abscesses19 (32.8)12 (42.9)7 (23.3)0.113
No. (%) with following vertebral area involved:
    C-spine1 (1.7)1 (3.6)00.579
    T-spine7 (12.1)5 (17.9)2 (6.7)
    TL-spine4 (6.9)2 (7.1)2 (6.7)
    L-spine32 (55.2)14 (50.0)18 (60.0)
    LS-spine13 (22.4)6 (21.4)7 (23.3)
    S-spine1 (1.7)01 (3.3)
No. (%) with following no. of vertebral bodies involved:
    18 (13.8)3 (10.7)5 (16.7)0.757
    235 (60.3)17 (60.7)18 (60.0)
    310 (17.2)8 (28.6)2 (6.7)
    ≥45 (8.6)05 (16.7)
Duration (days) of prior antibiotic exposuref7.0 (3.0–15.0)4.5 (2.3–14.3)7.5 (4.0–15.5)0.086
Antibiotic-free period (days)f1.5 (0.7–5.7)1.1 (0.2–3.3)3.3 (1.2–7.6)0.007
No. (%) undergoing biopsy by:
    Needle48 (82.8)21 (75.0)27 (90.0)0.173b
    Open surgery10 (17.2)7 (25.0)3 (10.0)
  • a Mean ± standard deviation.

  • b Fisher's exact test.

  • c Body temperature of ≥38.0°C.

  • d Motor power, ≤grade 4 (full range of movement but resisted by examiner) (8).

  • e Two or more of the following: body temperature of >38°C or <36°C, heart rate of >90/min, respiratory rate of >20/min or partial CO2 pressure of <32 mm Hg, WBC count of >12,000/mm3 or <4,000/mm3 or >10% bands.

  • f Median (interquartile range).