TABLE 2

Characteristics and positivity rates of tissue and/or blood cultures according to antibiotic-free periods in patients with PVO

ParameterAntibiotic-free period of:P value
<48 h (n = 32)≥48 to <120 h (n = 10)≥120 h (n = 16)
Mean age (yr) ± SD63.4 ± 14.366.5 ± 15.371.1 ± 13.10.209
No. (%) of males16 (50.0)5 (50.0)3 (18.8)0.052
No. (%) with fever12 (37.5)4 (40.0)4 (25.0)0.433
No. (%) with motor weakness4 (12.5)2 (20.0)4 (25.0)0.273
No. (%) with sepsis13 (40.6)4 (40.0)2 (12.5)0.065
No. (%) with lumbar spine involvement27 (84.4)9 (90.0)14 (87.5)0.730
No. (%) with >3 vertebral bodies involved9 (28.1)3 (30.0)3 (18.8)0.523
No. (%) with abscesses22 (68.8)9 (90.0)11 (68.8)0.844
No. of WBC/mm3a10,480 (9,158–14,375)10,950 (8,463–13,828)7,625 (6,718–10,025)0.023b
CRP level (mg/dl)a13.6 (6.8–19.3)15.0 (3.8–21.0)5.9 (1.6–11.3)0.089b
Prior antibiotic exposure duration (days)a4.0 (3.0–8.8)5.0 (2.8–12.8)17.0 (7.0–33.5)<0.001b
No. (%) with cephalosporin as prior antibiotic25 (78.1)4 (40.0)14 (87.5)0.768
No. (%) with quinolone as prior antibiotic5 (15.6)1 (10.0)5 (31.2)0.245
No. (%) with glycopeptide as prior antibiotic3 (9.4)1 (10.0)2 (12.5)0.747
No. (%) with open surgical biopsy8 (25.0)2 (20.0)00.037
No. of tissue cultures positive/total (%)20/32 (62.5)3/10 (30.0)5/16 (31.3)0.029
No. of blood culture positive/total (%)12/29 (41.4)2/10 (20.0)2/14 (14.3)0.058
  • a Median (interquartile range).

  • b P value calculated by one-way analysis of variance.