TABLE 2

MICs of colistin in site-directed mutants of NTUH-K2044

StrainMIC to colistinpmrH mRNA relative fold change (mean ± SD)
NTUH-K2044
    Wild type11
    MgrB Stop48Tyr325.30 ± 1.32
    PhoP Val3Phe1
    PhoP Ser86Leu1
    PhoQ Leu26Pro3239.64 ± 6.64
    PhoQ Asp150Gly1
    PhoQ Val258Phe1
    PmrB Arg256Gly1
ATCC 25922a1
  • a ATCC 25922 served as a quality control.