TABLE 2

Activity of arbekacin and comparator antimicrobial agents when tested against organisms isolated from pneumonia in hospitalized patients (United States, 2012)

Organism (no. of isolates tested) and antimicrobial agentMIC (μg/ml)% S/% I/% Ra
50%90%RangeCLSIEUCAST
S. aureus (100)
    Arbekacin0.250.50.12–4—/—/——/—/—
    Amikacin4160.5–>12896.0/3.0/1.085.0/11.0/4.0
    Gentamicin0.250.5≤0.06–>12895.0/0.0/5.094.0/0.0/6.0
    Tobramycin0.5>1280.12–>12876.0/0.0/24.076.0/0.0/24.0
    Vancomycin110.5–2100.0/0.0/0.0100.0/0.0/0.0
    Linezolid120.5–2100.0/0.0/0.0100.0/0.0/0.0
    Daptomycin0.250.50.12–0.5100.0/—/—100.0/0.0/0.0
    Clindamycin0.12>128≤0.06–>12877.0/1.0/22.077.0/0.0/23.0
    Oxacillin1>320.12–>3257.0/0.0/43.057.0/0.0/43.0
P. aeruginosa (100)
    Arbekacin140.12–64—/—/——/—/—
    Amikacin480.25–12898.0/1.0/1.096.0/2.0/2.0
    Gentamicin216≤0.06–>12888.0/1.0/11.088.0/0.0/12.0
    Tobramycin0.54≤0.06–>12890.0/1.0/9.090.0/0.0/10.0
    Aztreonam8320.25–12869.0/11.0/20.011.0/69.0/20.0
    Piperacillin-tazobactam464≤0.12–>12878.0/12.0/10.078.0/0.0/22.0
    Cefepime4160.25–3277.0/13.0/10.077.0/0.0/23.0
    Ceftazidime2320.25–12886.0/3.0/11.086.0/0.0/14.0
    Imipenem116≤0.06–3274.0/4.0/22.078.0/8.0/14.0
    Meropenem0.516≤0.06–3275.0/4.0/21.075.0/14.0/11.0
    Levofloxacin0.532≤0.015–>3276.0/3.0/21.064.0/12.0/24.0
    Colistin0.510.12–2100.0/0.0/0.0100.0/0.0/0.0
K. pneumoniae (102)
    Arbekacin0.2580.12–>128—/—/——/—/—
    Amikacin1320.5–>12888.2/9.8/2.086.3/1.9/11.8
    Gentamicin0.2580.12–>12889.2/2.0/8.884.3/4.9/10.8
    Tobramycin0.25320.12–>12882.4/2.9/14.777.5/4.9/17.6
    Aztreonam≤0.06>128≤0.06–>12877.5/0.0/22.577.5/0.0/22.5
    Piperacillin-tazobactam2>1281–>12886.3/0.0/13.780.4/5.9/13.7
    Cefepime≤0.0632≤0.06–>12883.3/1.0/15.780.4/2.0/17.6
    Ceftazidime0.25>128≤0.06–>12877.5/0.9/21.676.5/1.0/22.5
    Imipenem0.121≤0.06–>12893.1/0.0/6.993.1/1.0/5.9
    Meropenem≤0.060.12≤0.06–>12891.2/1.0/7.892.2/2.9/4.9
    Levofloxacin0.0632≤0.015–>3280.4/0.0/19.679.4/1.0/19.6
    Colistin0.250.250.12–>32—/—/—95.1/0.0/4.9
Enterobacter spp.b (100)
    Arbekacin0.510.25–4—/—/——/—/—
    Amikacin120.5–8100.0/0.0/0.0100.0/0.0/0.0
    Gentamicin0.510.12–12897.0/1.0/2.097.0/0.0/3.0
    Tobramycin0.510.12–6496.0/1.0/3.094.0/2.0/4.0
    Aztreonam0.1232≤0.06–>12873.0/4.0/23.072.0/1.0/27.0
    Piperacillin-tazobactam2640.5–>12878.0/14.0/8.071.0/7.0/22.0
    Cefepime≤0.062≤0.06–>12896.0/0.0/4.087.0/8.0/5.0
    Ceftazidime0.2564≤0.06–>12872.0/1.0/27.070.0/2.0/28.0
    Imipenem0.51≤0.06–297.0/3.0/0.0100.0/0.0/0.0
    Meropenem≤0.06≤0.06≤0.06–1100.0/0.0/0.0100.0/0.0/0.0
    Levofloxacin0.030.5≤0.015–>3297.0/1.0/2.096.0/1.0/3.0
    Colistin0.25160.12–>32—/—/—88.0/0.0/12.0
  • a Criteria as published by the CLSI (14) and EUCAST (15). —, no criteria available.

  • b Includes Enterobacter aerogenes (37 strains), E. asburiae (two strains), and E. cloacae (61 strains).