1 | Fit the full model; i.e., fit a linear regression (as defined by equation 3) to all *m* parasitemia values of subject *i* |

2 | Fit two models; i.e., fit the linear regression model to *m* − 1 parasitemia values by (i) removing the first observation and (ii) removing the last observation |

3 | Determine the best model of steps 2i and ii, defined as the model corresponding to the minimum overall model *P* value |

4 | Of the best model defined in step 3, repeat steps 2 and 3 in an iterative process until a minimum of four observations have been taken |

5 | Of the *m* − 3 best models selected per iteration (including the full model [step 1]), the optimal model is defined by the minimum overall model *P* value |