TABLE 2

Pharmacokinetic measures as means and corresponding ranges for Cmax, Tmax, t1/2, and AUC measurements of sulfadoxine and pyrimethamine

DrugMean (range)a
CmaxTmax (h)t1/2 (days)AUC0–96AUC0–∞
Sulfadoxine135 mg/liter (110–176)10.8 (4–36)7.3 (4.9–13.2)10,044 (8,422–12,244)31,848 (21,705–49,365)
Pyrimethamine714 μg/liter (610–832)3.8 (2–8)3.9 (2.1–6.5)42,701 (33,922–53,872)87,786 (51,612–140,201)
  • a AUC0–96 and AUC0–∞, AUC from 0 to 96 h and from 0 h to infinity, respectively.