TABLE 1

Summary of plasma PK parameters for cefazolin derived by noncompartmental methods

Parameter (unit) and statisticPediatric surgical patientsNormal, healthy adultsa
1 g (n = 8)2 g (n = 4)Overall (n = 12)
Cmax (mg/liter)
    n841212
    Mean224302250281
    %CV13.624.023.716.4
    Geometric mean222296244277
    G%CV13.123.921.717.2
    Min195244195211
    Max271394394354
AUC0–last (mg · h/liter)
    n841212
    Mean507705573480
    %CV14.319.623.415.5
    Geometric mean502694559475
    G%CV14.920.922.915.3
    Min389522389396
    Max585853853611
AUC0–∞ (mg · h/liter)
    n841212
    Mean539743607510
    %CV17.519.724.217.5
    Geometric mean531731591503
    G%CV17.921.124.117.3
    Min402549402404
    Max675899899670
CL (ml/min/kg)
    n8412
    Mean0.8310.7750.813
    %CV14.713.514.1
    Geometric mean0.8230.7700.805
    G%CV41.138.039.8
    Min0.6090.6730.609
    Max0.9850.8940.985
Vz (liters/kg)
    n8412
    Mean0.1410.1300.137
    %CV28.19.1223.7
    Geometric mean0.1360.1300.134
    G%CV55.130.449.3
    Min0.1000.1210.100
    Max0.2050.1470.205
t1/2 (h)
    n8412
    Mean1.961.951.95
    %CV23.96.1719.4
    Geometric mean1.911.941.9
    G%CV22.86.2018.4
    Min1.441.811.48
    Max2.882.082.88
  • a The AUC0–8h is used for the AUC0–last from the adult data to ensure that the same time interval is covered for comparison.