Parameter | Population mean (%CV) | Magnitude of IIV (%CV) | ||
---|---|---|---|---|

Final estimate | Bootstrap %SEM | Final estimate | Bootstrap %SEM | |

CL_{R} (liters/h) coefficient | 3.63 | 3.15 | 0.0122 (11.0) | 33.3 |

PEDS shift | −0.335 | 22.9 | ||

CL_{CR} power | 0.337 | 51.3 | ||

IOV | 1.0 | 0.0115 (11.0) | 20.2 | |

V_{c} (liters) coefficient | 4.72 | 4.84 | 0.0351 (18.7) | 30.4 |

CL_{d} (liters/h) coefficient | 7.89 | 11.0 | ||

V_{p} (liters) coefficient | 3.70 | 3.52 | ||

Residual-variability model | ||||

Constant CV component | 0.0112 (10.6) | 10.5 | ||

Additive component | 0.845 | 48.5 |

↵a Cefazolin total clearance is calculated as CL = [0.153 + 3.63 × (CL

_{CR}/90)^{0.75}(1 − 0.335 × PEDS) × exp(IIV + IOV × day), where CL_{CR}is creatinine clearance in ml/min/1.73 m^{2}, PEDS (population indicator variable) = 0 for an adult subject, PEDS = 1 for a pediatric patient, day = 0 for day 1, and day = 1 for day 11. The cefazolin*V*_{1}and apparent volume of distribution in the peripheral compartment are multiplied by (WTKG/70)^{1}, where WTKG is weight in kg. The cefazolin CL_{d}(distribution clearance) coefficient is multiplied by (WTKG/70)^{0.75}. Residual variability, calculated as [(*Cp*× σ_{ij}_{CCV}+ σ_{add})/*Cp*] × 100 (where σ_{ij}_{CCV}is the constant CV component and σ_{add}is the additive component), was 95.1, 19.1, 11.4, and 10.8% CV for plasma cefazolin concentrations (*Cp*) of 1, 10, 100, and 500 mg/liter, respectively._{ij}