TABLE 1

Summary of the bactericidal effects of olanexidine against various bacterial strains by exposure time and MBCa

Strain tested (no. of strains)Exposure time (s)Minimal bactericidal concn (range) (μg/ml) for:
Olanexidine gluconateChlorhexidine digluconatePovidone-iodine
Gram-positive cocci except Enterococcus spp. (21)3013.6 to 1,74039.1 to >2,500≤48.8 to 781
60≤6.8 to 8699.8 to >2,500≤48.8 to 781
180≤6.8 to 4349.8 to >1,250≤48.8 to 391
Enterococcus spp. (34)3013.6 to 4345,000 to >5,000195 to >50,000
60≤6.8 to 21778.1 to >5,00097.7 to >50,000
180≤6.8 to 54.39.8 to >5,000≤48.8 to 1,560
Gram-positive bacilli (9)30≤6.8 to 1,74019.5 to >2,50097.7 to 781
60≤6.8 to 1,74019.5 to >2,500≤48.8 to 781
180≤6.8 to 1099.8 to >2,50097.7 to 781
Gram-negative strains except Burkholderia cepacia (34)30≤6.8 to 86939.1 to >5,000≤48.8 to 3,130
60≤6.8 to 43419.5 to >5,000≤48.8 to 781
180≤6.8 to 54.3≤4.9 to 2,500≤48.8 to 781
B. cepacia (2)30>6,950>5,000391
601,740 to >6,950>5,000391
180434625195
  • a The full data set is given in Table S1 in the supplemental material.