TABLE 2

MBCs of olanexidine against clinical isolates

Strain (no. of strains)Exposure time (s)Minimal bactericidal concn (range) (μg/ml) for:
Olanexidine gluconateChlorhexidine digluconatePovidone-iodine
Methicillin-resistant S. aureus (30)a30217 to >3,4802,500 to >5,000781 to 1,560
60217 to 8692,500 to >5,000781 to 1,560
18054.3 to 2172,500 to >5,000195 to 781
Methicillin-susceptible S. aureus (20)30217 to >3,480156 to >2,500391 to 1,560
60217 to 1,74078.1 to >2,500195 to 781
180≤6.8 to 869≤4.9 to 156≤48.8 to 781
Coagulase-negative Staphylococcus (20)30217 to >869156 to >1,250195 to 1,560
60109 to 86939.1 to >1,25097.7 to 1,560
18013.6 to 10919.5 to >625≤48.8 to 781
E. faecalis (30)a3054.3 to 434625 to >5,000781 to 50,000
6027.1 to 217313 to >5,000391 to 3,130
18013.6 to 109156 to 5,000195 to 1,560
Corynebacterium spp. (20)30≤6.8 to 54.3≤4.9 to >78.1≤48.8 to 781
60≤6.8 to 27.1≤4.9 to >78.1≤48.8 to 391
180≤6.8 to 13.6≤4.9 to 78.1≤48.8 to 391
E. coli (20)3054.3 to 21719.5 to 625195 to 781
6054.3 to 2179.8 to 31397.7 to 781
18027.1 to 109≤4.9 to 78.1≤48.8 to 391
P. aeruginosa (20)3027.1 to 86939.1 to >5,000195 to 781
6013.6 to 21739.1 to >5,000195 to 781
180≤6.8 to 54.319.5 to 313195 to 781
K. pneumoniae (20)3013.6 to 54.319.5 to 78.1195 to 781
60≤6.8 to 27.119.5 to 78.197.7 to 391
180≤6.8 to 27.19.8 to 39.1≤48.8 to 391
A. baumannii (20)3013.6 to 10939.1 to 156≤48.8 to 391
6013.6 to 54.319.5 to 156≤48.8 to 391
18013.6 to 27.19.8 to 78.1≤48.8 to 391
S. marcescens (20)3027.1 to 3,48078.1 to >5,00097.7 to 391
6013.6 to 43439.1 to >5,00097.7 to 391
18013.6 to 21719.5 to 78.197.7 to 391
  • a These data were collected in the current study but are included in reference 7, which was published first.