TABLE 3

Binding affinity of olanexidine to bacterial surface molecules, as determined by the Bodipy TR cadaverine displacement assay

Bacterial surface moleculeMedian effective dose (95% confidence interval) (╬╝mol/liter) for:
Olanexidine gluconateChlorhexidine digluconatePolymyxin B sulfate salt (positive control)Alexidine dihydrochloride (positive control)
LPS-bound BC20 (18 to 22)210 (98 to 440)3.8 (2.6 to 5.6)Not tested
Lipid A-bound BC15 (14 to 15)30 (27 to 33)3.1 (2.8 to 3.3)Not tested
LTA-bound BC43 (37 to 50)680 (610 to 760)Not tested18 (14 to 22)