TABLE 1

MIC99 values for PyrBTZ01 and PyrBTZ02 against wild-type and BTZ-resistant mycobacterial strains

StrainAmino acid at position 387MIC99 (μg/ml)
PyrBTZ01PyrBTZ02BTZ043
M. tuberculosis H37RvCys0.160.160.001
M. tuberculosis NTB1Ser100>10010
M. tuberculosis ss18bCys>100>100>10
M. smegmatis mc2155Cysa0.780.390.004
M. smegmatis MN47Glya>100>1004
M. smegmatis MN84Sera>100>100>16
M. bovis BCGCys0.390.20.003
M. bovis BCG BN2Ser25>100>16
  • a The active site cysteine in M. smegmatis DprE1 is Cys394.