TABLE 2

IC50 values measured for PyrBTZ01, PyrBTZ02, and BTZ043 against wild-type and BTZ-resistant M. tuberculosis DprE1

CompoundIC50 (μM)
Wild-typeC387GC387S
PyrBTZ011.6111.44.00
PyrBTZ027.34>4027.7
BTZ0430.004250.03950.0108