TABLE 4

Metabolic stability of PyrBTZ01 and PyrBTZ02 in the presence of mouse and human microsomes

CompoundCLint (μl/min/mg protein)
Mouse microsomesHuman microsomes
Carbamazepine2.100.60
PyrBTZ0122.712.2
PyrBTZ0216.222.3
BTZ04316.54.20
PBTZ16936.720.8