TABLE 1

Demographic, clinical, and laboratory characteristics of 162 hospitalized adults treated with intravenous AmB at a university hospitala

Baseline variablesAll (n = 162)Type of AmB preparationP value
Deoxycholate (n = 120)Liposomal (n = 42)
Age (n = 161) (median [IQR]) (yr)35 (25–51)36 (24–51)33 (28–50)0.903
    Age quartiles (no. [%]) (yr)
        ≤2543 (26.7)35 (29.4)8 (19.0)0.122
        26–3540 (24.8)24 (20.2)16 (38.1)
        36–5038 (23.6)30 (25.2)8 (19.0)
        >5040 (24.8)30 (25.2)10 (23.8)
Gender (no. [%])0.187
    Male92 (56.8)64 (53.3)28 (66.7)
    Female70 (43.2)56 (46.7)14 (33.3)
Residence (n = 160) (no. [%])0.002
    Rural areas95 (59.4)61 (51.7)34 (81.0)
    Capital65 (40.6)57 (48.3)8 (19.0)
AmB indication (no. [%])0.000
    Teg. leishmaniasis33 (20.4)11 (9.2)22 (52.4)
    Visc. leishmaniasis12 (7.4)5 (4.2)7 (16.7)
    Suspected IFE26 (16.0)22 (18.3)4 (9.5)
    Confirmed IFE40 (24.8)34 (28.3)6 (14.3)
    FUO36 (22.2)34 (28.3)2 (4.8)
    Other15 (9.3)14 (11.7)1 (2.4)
Charlson index (no. [%])0.006
    0–165 (40.1)40 (33.3)25 (59.5)
    2–359 (36.4)51 (42.5)8 (19.0)
    ≥438 (23.5)29 (24.2)9 (21.4)
Disease severity (no. [%])c
    Intensive care unit53 (32.7)48 (40.0)5 (11.9)0.002
    Vasopressor drugs35 (21.6)30 (25.0)5 (11.9)0.119
    Mechanical ventilation42 (26.1)38 (31.7)5 (11.9)0.022
Serum lab values (median [IQR])
    Cr (n = 162) (mg/dl)0.8 (0.7–1.1)0.8 (0.6–1.1)0.9 (0.8–1.1)0.350
    BUN (n = 103) (mg/dl)12.1 (7.9–18.2)12.6 (7.9–22.1)11.7 (10.3–14.5)0.088
    K+ (n = 98) (meq/liter)4.0 (3.6–4.4)3.9 (3.6–4.3)4.0 (3.6–4.5)0.906
    Mg2+ (n = 73) (mg/dl)1.8 (1.6–2.0)1.8 (1.6–2.0)1.8 (1.6–2.2)0.614
    HCO3 (n = 28) (meq/liter)21.6 (16.7–26.3)22.2 (17.7–26.2)18.7 (16.1–32.7)0.779
    Lactate (n = 23) (mmol/liter)1.6 (1.2–2.0)1.5 (1.2–2.0)2.0 (1.1–2.2)0.822
  • a AmB amphotericin B.

  • b Teg., tegumentary; Visc., visceral; IFE, invasive fungal infection; FUO, fever of unknown origin; BUN, blood urea nitrogen.

  • c Intensive care unit, vasopressor drugs or mechanical ventilation reflect the need for these types of care at any point during the admission.