TABLE 5

Univariate and multivariate Cox regression analyses to identify independent predictors of AKI by KDIGObin, NT0.5, and NT2×

AKI criteria predictors^a	Univariate analysis (HR [95% CI])	P value^b	Multivariate (HR [95% CI])	P value^b
KDIGObin
Age (yr)	1.09 (1.00–1.02)	0.143
Deoxycholate preparation	1.15 (0.72–1.83)	0.569
ICU initiation	1.20 (0.71–2.03)	0.497
Leishmaniasis	1.10 (0.71–1.70)	0.679
Charlson index ≥4	1.18 (0.37–3.77)	0.776
Furosemide	1.42 (0.91–2.21)	0.127
ACE-I	1.52 (0.93–2.50)	0.095	1.53 (0.92–2.53)	0.100
Polymyxin B	0.73 (0.35–1.50)	0.384
Vancomycin	1.16 (0.77–1.76)	0.466
Vasopressors	1.10 (0.68–1.80)	0.693
NT0.5
Age (yr)	1.01 (1.00–1.02)	0.104	1.01 (1.00–1.04)	0.084
Deoxycholate preparation	1.68 (0.94–3.02)	0.080
ICU initiation	1.59 (0.91–2.77)	0.102
Leishmaniasis	0.83 (0.49–1.41)	0.833
Charlson index ≥4	1.07 (0.63–1.83)	0.793
Furosemide	1.52 (0.92–2.51)	0.101
ACE-I	1.29 (0.73–2.28)	0.374
Polymyxin B	0.92 (0.42–2.00)	0.826
Vancomycin	1.70 (1.07–2.69)	0.024	1.76 (1.10–2.78)	0.018
Vasopressors	1.45 (0.86–2.45)	0.162
NT2×
Age (yr)	1.00 (0.98–1.02)	0.889
Deoxycholate preparation	2.00 (0.89–4.48)	0.092
ICU initiation	2.07 (1.17–4.01)	0.031
Leishmaniasis	0.51 (0.24–1.09)	0.082
Charlson index ≥4	1.21 (0.63–2.34)	0.571
Furosemide	1.67 (0.89–3.14)	0.112
ACE-I	1.50 (0.74–3.02)	0.261
Polymyxin B	1.09 (0.43–2.77)	0.853
Vancomycin	2.39 (1.32–4.33)	0.004	2.00 (1.08–3.71)	0.028
Vasopressors	2.58 (1.41–4.71)	0.002	2.08 (1.11–3.91)	0.022

↵a Age was evaluated as a continuous variable; all other independent variables are categorical.
↵b Variables with a P value of <0.20 in univariate analyses (in bold type) were included in a multivariate backward logistic regression model. Only the variables remaining at the final model are shown.