TABLE 5

Univariate and multivariate Cox regression analyses to identify independent predictors of AKI by KDIGObin, NT0.5, and NT2×

AKI criteria predictorsaUnivariate analysis (HR [95% CI])P valuebMultivariate (HR [95% CI])P valueb
KDIGObin
    Age (yr)1.09 (1.00–1.02)0.143
    Deoxycholate preparation1.15 (0.72–1.83)0.569
    ICU initiation1.20 (0.71–2.03)0.497
    Leishmaniasis1.10 (0.71–1.70)0.679
    Charlson index ≥41.18 (0.37–3.77)0.776
    Furosemide1.42 (0.91–2.21)0.127
    ACE-I1.52 (0.93–2.50)0.0951.53 (0.92–2.53)0.100
    Polymyxin B0.73 (0.35–1.50)0.384
    Vancomycin1.16 (0.77–1.76)0.466
    Vasopressors1.10 (0.68–1.80)0.693
NT0.5
    Age (yr)1.01 (1.00–1.02)0.1041.01 (1.00–1.04)0.084
    Deoxycholate preparation1.68 (0.94–3.02)0.080
    ICU initiation1.59 (0.91–2.77)0.102
    Leishmaniasis0.83 (0.49–1.41)0.833
    Charlson index ≥41.07 (0.63–1.83)0.793
    Furosemide1.52 (0.92–2.51)0.101
    ACE-I1.29 (0.73–2.28)0.374
    Polymyxin B0.92 (0.42–2.00)0.826
    Vancomycin1.70 (1.07–2.69)0.0241.76 (1.10–2.78)0.018
    Vasopressors1.45 (0.86–2.45)0.162
NT2×
    Age (yr)1.00 (0.98–1.02)0.889
    Deoxycholate preparation2.00 (0.89–4.48)0.092
    ICU initiation2.07 (1.17–4.01)0.031
    Leishmaniasis0.51 (0.24–1.09)0.082
    Charlson index ≥41.21 (0.63–2.34)0.571
    Furosemide1.67 (0.89–3.14)0.112
    ACE-I1.50 (0.74–3.02)0.261
    Polymyxin B1.09 (0.43–2.77)0.853
    Vancomycin2.39 (1.32–4.33)0.0042.00 (1.08–3.71)0.028
    Vasopressors2.58 (1.41–4.71)0.0022.08 (1.11–3.91)0.022
  • a Age was evaluated as a continuous variable; all other independent variables are categorical.

  • b Variables with a P value of <0.20 in univariate analyses (in bold type) were included in a multivariate backward logistic regression model. Only the variables remaining at the final model are shown.